In Silico Molecular Docking Analysis of Natural Pyridoacridines as Anticancer Agents

Table 2

Different glide parameters.

S. Number	Pyridoacridine analogues (cancer macromolecule)	Glide GScore	Glide energy	Glide Van der Waals energy	Glide coulomb energy
1	Meridine (CDK-6)	−9.53	−44.78	−41.76	−3.02
2	Neoamphimedine (CDK-6)	−7.66	−34.96	−34.82	−0.14
3	Deoxyamphimedine (CDK-6)	−7.48	−41.60	−38.27	−3.33
4	Amphimedine (CDK-6)	−7.16	−40.63	−41.24	0.60
5	Meridine (IGF-1R kinase)	−6.78	−44.09	−42.52	−1.57
6	Neoamphimedine (IGF-1R kinase)	−6.48	−41.33	−39.44	−1.89
7	Meridine (CDK-2)	−6.21	−40.89	−39.54	−1.34
8	Amphimedine (CDK-2)	−6.05	−44.34	−41.46	−2.87
9	Amphimedine (IGF-1R kinase)	−6.02	−29.46	−27.51	−1.94
10	Varamine A (CDK-2)	−5.84	−47.92	−42.23	−5.69
11	Deoxyamphimedine (CDK-2)	−5.71	−37.91	−36.76	−1.15
12	Varamine A (Bcl-2)	−5.63	−35.25	−31.74	−3.51
13	Deoxyamphimedine (IGF-1R kinase)	−5.50	−38.44	−34.48	−3.96
14	Neoamphimedine (CDK-2)	−5.31	−43.00	−40.81	−2.18
15	Meridine (Bcl-2)	−4.95	−28.73	−28.83	0.09
16	Deoxyamphimedine (Bcl-2)	−4.94	−31.28	−28.66	−2.61
17	Varamine A (IGF-1R kinase)	−4.91	−35.32	−31.13	−4.18
18	Neoamphimedine (Bcl-2)	−4.47	−28.84	−28.34	−0.49
19	Amphimedine (Bcl-2)	−4.38	−28.37	−29.58	1.20
20	Varamine A (CDK-6)	−2.95	−41.06	−39.55	−1.50
21	Amphimedine (VEGFR-2)	−1.80	−25.09	−23.61	−1.48
22	Neoamphimedine (VEGFR-2)	−1.67	−21.12	−19.54	−1.57
23	Meridine (G-Quadruplex)	−1.00	−29.99	−25.94	−4.05
24	Varamine A (G-Quadruplex)	−0.97	−37.20	−31.10	−6.09
25	Deoxyamphimedine (G-Quadruplex)	−0.94	−35.56	−30.01	−5.55
26	Amphimedine (G-Quadruplex)	0.42	−34.38	−34.03	−0.34
27	Neoamphimedine (G-Quadruplex)	0.49	−32.96	−32.41	−0.54