Research Article
Flow and Microwave Induced Pellizzari Reactions: Synthesis of Heterocyclic Analogues of the Benzoxazepine Antipsychotic Agents Loxapine and JL-13
Table 1
Intramolecular cyclization to form triazolo benzoxepines 3 (% isolated yield).
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-BuOH, , 118°C, 6 h; W, 200°C, -BuOH 15 min. pumps of the reactor were set to flow at equal rates (2 μl/min) at 190°C with a solution of 5-chlorobenzo[b]pyrido[,-f][,]oxazepine (0.04 M) and hydrazide (0.04 M) in -BuOH with residence time of 2.5 min. Experiments represent . |