QSAR Study of Anthra[1,9-cd]pyrazol-6(2H)-one Derivatives as Potential Anticancer Agents Using Statistical Methods

Table 6

The proposed novel compounds.

Comp.	R1	R2		MW	MV	Density	PIC50 RLM	PIC50 RNLM	PIC50 PLS
X1	H	H		237.26	147.4	1.6	1.52	1.44	1.58
X2	OH	H		253.26	152.6	1.65	1.48	1.3	1.51
X3	COOH	H		281.27	166	1.69	1.36	1.14	1.38
X4	CN	H		262.27	168.2	1.55	0.85	1.17	0.93
X5	CH2OH	H		267.28	168.7	1.58	1.42	1.23	1.49
X6	CH2Cl	H		285.73	180.7	1.58	1	1.05	1.05
X7	CCl3	H		354.62	204.7	1.73	0.71	1.26	0.75
X8	H	CH2CH2OH		281.31	182.9	1.53	1.38	1.23	1.47
X9	OH	CH2CH2OH		297.31	188.1	1.57	1.29	1.06	1.35
X10	COOH	CH2CH2OH		325.32	201.5	1.61	1.25	1.04	1.29
X11	CN	CH2CH2OH		306.32	203.7	1.5	1.2	1.01	1.19
X12	CH2OH	CH2CH2OH		311.34	204.2	1.52	1.33	1.19	1.39
X13	CH2Cl	CH2CH2OH		329.78	216.2	1.52	0.93	0.94	0.99
X14	CCl3	CH2CH2OH		398.67	240.2	1.65	0.53	1.23	0.59
X15	(C6H10)2	CH2CH2OH		445.6	332.6	1.33	1.52	1.91	1.42