QSAR Study of Anthra[1,9-cd]pyrazol-6(2H)-one Derivatives as Potential Anticancer Agents Using Statistical Methods

Table 7

Violations of Lipinski rule.

Comp.		DH	AH		Number of violations
1	4,18	1	3	254,67	0
2	4,30	2	4	291,35	0
3	3,98	2	4	277,33	0
4	3,53	3	5	321,38	0
5	5,10	2	4	339,40	1
6	4,98	2	4	317,39	0
7	4,42	2	4	303,37	0
8	5,59	2	4	331,42	1
9	3,28	3	5	293,33	0
10	4,54	2	4	291,35	0
11	3,22	2	4	249,27	0
12	4,94	2	4	325,37	0
13	6,35	2	4	345,45	1
14	5.00	2	5	369,42	0
15	5.00	2	5	369,42	0
16	4,85	2	6	383,41	0
17	3,24	1	4	298,73	0
18	3,36	2	5	335,41	0
19	3,04	2	5	321,38	0
20	2,59	3	6	365,43	0
21	4,16	2	5	383,45	0
22	4,04	2	5	361,45	0
23	3,48	2	5	347,42	0
24	4,65	2	5	375,47	0
25	2,34	3	6	337,38	0
26	3,60	2	5	335,41	0
27	2,28	2	5	293,33	0
28	4.00	2	5	369,42	0
29	5,41	2	5	389.50	1
30	4,06	2	6	413,48	0
31	3,90	2	6	399,45	0
32	3,75	2	7	413,43	0