Table of Contents Author Guidelines Submit a Manuscript
Advances in Condensed Matter Physics
Volume 2014, Article ID 176862, 6 pages
Review Article

Nanoparticle Imaging with Polarization Interferometric Nonlinear Confocal Microscope

Faculty of Engineering, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu 432-8561, Japan

Received 8 January 2014; Revised 1 April 2014; Accepted 2 April 2014; Published 27 April 2014

Academic Editor: Kai Sun

Copyright © 2014 Kohei Fujita and Chikara Egami. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Polarization interferometric nonlinear confocal microscope has been developed for single nanoparticle analysis of drug delivery system (DDS). The microscope is a system based on a low cost and low power continuous wave (CW) laser light source. Also, the microscope observed shape anisotropy of the 200 nm diameter nanoparticle. According to nanoparticle imaging and CTF (contrast transfer function) curve observation of the microscope, three-dimensional resolution of the microscope measured up to 10 nm.