Analytical Cellular Pathology

Analytical Cellular Pathology / 1998 / Article

Open Access

Volume 16 |Article ID 974145 |

José Antonio Alvarez-Riesgo, Andrés Sampedro, Radhamés Hernández, María Victoria Folgueras, Ana Salas-Bustamante, Antonio Cueto, "Cell Proliferation Activity and Prognostic Index in Squamous Cell Lung Carcinoma", Analytical Cellular Pathology, vol. 16, Article ID 974145, 10 pages, 1998.

Cell Proliferation Activity and Prognostic Index in Squamous Cell Lung Carcinoma

Received16 Dec 1997
Accepted05 Jun 1998


Flow Cytometry (FC) has been incorporated into cancer research in relation to its prognostic value together with histological parameters and TNM stages. We have studied by means of FC the cell cycle of 132 samples from male patients with Squamous Cell Lung Carcinoma (SQCLC). All of the patients received curative surgery and the clinical follow-up was 60 months. The clinical and cytometric parameters were evaluated in order to predict the patients’ outcome. The presence of tumoural recurrence and the tumoural stage showed statistical significance associated with survival. The multivariant analysis reveals radiotherapy (p = 0.004) as protective variable and the high S-phase fraction (SPF) (p = 0.001) and stage IIIA (p = 0.012) as risk factors. The SPF appears as an independent prognostic factor for overall survival time. We can build a prognostic index representative of different prognostic groups, which allows us to improve the individual monitoring of these patients.

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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