Analytical Cellular Pathology

Analytical Cellular Pathology / 2006 / Article

Open Access

Volume 28 |Article ID 619539 |

Constanze Will, Christiane Schewe, Karsten Schluns, Iver Petersen, "HPV Typing and CGH Analysis for the Differentiation of Primary and Metastatic Squamous Cell Carcinomas of the Aerodigestive Tract", Analytical Cellular Pathology, vol. 28, Article ID 619539, 9 pages, 2006.

HPV Typing and CGH Analysis for the Differentiation of Primary and Metastatic Squamous Cell Carcinomas of the Aerodigestive Tract


Human papilloma virus (HPV) typing and Comparative Genomic Hybridisation (CGH) analysis can be used in the classification of multiple tumours of the aerodigestive tract for the differentiation between secondary malignancy versus metastasis. We present 3 exemplary cases of patients with multiple squamous cell carcinomas, localised within the head and neck region, cervical lymph node and the lung. In two patients, HPV typing identified HPV type 16 in the tonsillar carcinomas and the corresponding cervical lymph node and lung carcinoma indicating that the latter were metastatic spreads. In case 1, CGH confirmed the clonal relationship. Case two showed a peculiar syncytial growth pattern with lymphocytic infiltration which may constitute a potential morphological marker for HPV infection. In case three, a vallecular carcinoma was HPV negative while a lung cancer was positive for HPV type 6 indicating two independent primary tumours. Our case triplet illustrates the variability of HPV infection in squamous cell cancer of the aerodigestive tract and power as well as limitations of morphology, HPV typing and tumour genetics in the classification of multiple tumours.

Copyright © 2006 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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