Analytical Cellular Pathology

Analytical Cellular Pathology / 2012 / Article
Special Issue

1st Congress of the International Academy of Digital Pathology Quebec City, Canada, August 3–5, 2011. Part II

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Open Access

Volume 35 |Article ID 154735 | 9 pages |

Color Standardization Method and System for Whole Slide Imaging Based on Spectral Sensing


In the field of whole slide imaging, the imaging device or staining process cause color variations for each slide that affect the result of image analysis made by pathologist. In order to stabilize the analysis, we developed a color standardization method and system as described below: 1) Color standardization method based on RGB imaging and multi spectral sensing, which utilize less band (16 bands) than conventional method (60 bands), 2) High speed spectral sensing module. As a result, we confirmed the following effect: 1) We confirmed the performance improvement of nucleus detection by the color standardization. And we can conduct without training data set which is needed in conventional method, 2) We can get detection performance of H&E component equivalent to conventional method (60 bands). And measurement process is more than 255 times faster.

Copyright © 2012 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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