Observer Performance in the Use of Digital and Optical Microscopy for the Interpretation of Tissue-Based Biomarkers

Table 5

Comparison of overall interobserver agreement between the assessment of Ki-67 with optical microscope and digital environment, using Kendall’s tau- metric [95% CI].

Interobserver Ki-67	Kendall’s tau- on continuous scores
	Optical	Digital	Difference
Whole slides	0.75 [0.63–0.84]	0.76 [0.61–0.86]	−0.01 [−0.13–0.12]
TMA	0.71 [0.63–0.78]	0.74 [0.65–0.80]	−0.03 [−0.09–0.04]