Prognostic Efficacy of Nuclear Morphometry at Invasive Front of Oral Squamous Cell Carcinoma: An Image Analysis Microscopic Study

Table 1

This table depicts the new malignancy grading system of oral squamous cell carcinoma patients as proposed by Anneroth et al. (1986) [6] and Bryne et al. (1989 and 1991) [7, 8].

Morphologic parameter	Histological grading of malignancy of tumor cell population
	1	2	3	4
Degree of keratinization	Highly keratinized (>50% of the cells)	Moderately keratinized (20–50% of the cells)	Minimal keratinization (5–20% of the cells)	No keratinization (0–5% of the cells)
Nuclear polymorphism	Little nuclear polymorphism (>75% mature cells)	Moderately abundant nuclear polymorphism; (50–75% mature cells)	Abundant nuclear polymorphism (25–50% mature cells)	Extreme nuclear polymorphism (0–25% mature cells)
Number of mitoses/HPF	0-1	2-3	4-5	>5
Pattern of invasion	Pushing well-delineated infiltrating borders	Infiltrating, solid cords, bands and/or strands	Small groups or cords of infiltrating cells ()	Marked and wide spread cellular dissociation in small groups of cells () and/or in single cells
Lymphoplasmacytic infiltration	Marked	Moderate	Slight	None