Salivary RNA Signatures in Oral Cancer Detection

Table 1

Various salivary transcriptomes and their role in oral carcinogenesis.

Transcriptome	Role in metabolism and oral carcinogenesis
DUSP1	DUSP mRNA participates in the MAPK pathway. Hypermethylation of DUSP1 gene is associated with oral carcinogenesis [23–25].
H3F3A	It maintains the integrity of chromosomal nucleosome and is a proliferative marker [5, 26].
IL IB	It is chemical mediator of cell proliferation, differentiation, and apoptosis [27, 28].
IL 8	It is a player in tumor angiogenesis, cell adhesion, and cell cycle arrest [29–31].
OAZ1	It regulates polyamine synthesis and is a tumor suppressor [5, 32, 33].
SAT	It is responsible for catabolism of polyamines [35].
S100 P	It is responsible for cell cycle regulation and differentiation [36].
miR-125a	It affects genes in MAPK pathway and in cell proliferation [45].
miR-200a	It plays an important role in tumor suppression and early metastasis [46, 47].
miR-31	This is a tumor suppressor [44, 48].