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Analytical Cellular Pathology
Volume 2015 (2015), Article ID 159549, 5 pages
Research Article

Effect of Acute and Chronic Exposure to High Altitude on the Aerobic and Anaerobic Metabolism in Rats

1Department of Pediatrics, Lanzhou University Second Hospital, Lanzhou 730000, China
2Laboratory of Pediatrics, Lanzhou University Second Hospital, Lanzhou 730000, China
3Institute of Anatomy, School of Basic Medicine, Lanzhou University, Lanzhou 730000, China
4Department of General Surgery, Hepatic-Biliary-Pancreatic Institute, Lanzhou University Second Hospital, Lanzhou 730000, China

Received 5 July 2015; Accepted 29 October 2015

Academic Editor: José A. Sánchez-Alcázar

Copyright © 2015 Qian Ni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this study, we aimed to investigate the effect of acute and chronic exposure to HA on the aerobic and anaerobic metabolism in liver by determining the hepatic levels of ICDH and ATP. Lactate levels in liver and blood were also examined. Rats were exposed to an altitude of 4,300 m for 30 days, and those without HA exposure were used as controls. We observed an increased expression of liver ICDH following acute exposure (days 1, 3, and 7), whereas the liver ATP concentration was reduced on day 1. No changes in the hepatic expression of ICDH and ATP were found in rats chronically exposed to HA. Lactate concentrations of liver and blood did not show any significant changes following HA exposure. Thus, aerobic metabolism may be the major metabolic pathway in response to HA hypoxia in order to acclimatize themselves to the stressful environments.