Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice

Figure 6

Quercetin inhibits the oxidative stress induced by Ehrlich tumor cells. Mice were treated with quercetin (100 mg/kg, i.p.) or vehicle 10 min after the injection of Ehrlich tumor cells (1 × 10⁶/25 μL) or saline. The treatment continued daily during 12 days, and, in the 12th day, 3 h after the treatment, samples of spinal cord and paw skin were collected for the oxidative stress assays. The FRAP and ABTS ability of spinal cord ((a) and (c), resp.) and paw skin ((b) and (d), resp.) tissues and GSH levels in spinal cord (e) and paw skin (f) were accessed. Data are presented as means ± SEM of six mice per group per experiment and representative of two separated experiments: compared to the saline group and compared to the tumor group. One-way ANOVA followed by Tukey’s test.

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