Analytical Cellular Pathology / 2015 / Article / Tab 2

Research Article

Genetic Polymorphism and Expression of CXCR4 in Breast Cancer

Table 2

Clinicopathological parameters analysis according to rs2228014 CXCR4 genetic polymorphism in breast cancer patients.

Total
(%)
CXCR4 genotypep value
CCAllele T carrier
(%) (%)

Tumor histologyIDC45 (90.0)40 (80.0)05 (10.0)0.686
ILC02 (4.0)01 (2.0)01 (2.0)
Others03 (6.0)03 (6.0)00 (0.0)

Nuclear gradeI11 (22.0)08 (17.4)03 (6.5)0.312
II16 (34.7)14 (30.4)02 (4.3)
III19 (41.3)19 (41.3)00 (0.0)

Nodal statusNegative27 (60.0)22 (48.9)05 (11.1)0.697
Positive18 (40.0)17 (37.8)01 (2.2)

ER statusNegative06 (12.5)06 (12.5)00 (0.0)0.630
Positive42 (87.5)36 (75.0)06 (12.5)

PR statusNegative10 (20.8)10 (20.8)00 (0.0)0.287
Positive38 (79.2)32 (66.7)06 (12.5)

p53Negative33 (75.0)27 (61.4)06 (13.6)0.789
Positive11 (25.0)11 (25.0)00 (0.0)

Ki67Low17 (44.8)12 (31.6)05 (13.2)0.129
Moderate05 (13.1)04 (10.5)01 (2.6)
High18 (42.1)16 (42.1)00 (0.0)

HER2Negative32 (71.1)27 (60.0)05 (11.1)0.818
Positive13 (28.9)12 (26.7)01 (2.2)

IDC: Invasive Ductal Carcinoma; ILC: Invasive Lobular Carcinoma; others: CMI, ductal carcinoma in situ.