Analytical Cellular Pathology / 2015 / Article / Tab 1

Review Article

The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis

Table 1

Traditional and potential therapies for osteoporosis.

Molecular targetMechanism of actionApproved agent

Prenylation Osteolysis inhibitorZoledronic acid and other bisphosphonates
RANK/RANKL/OPG axisOsteoclastogenesis inhibitorDenosumab
Recombinant osteoprotegerin (OPG) Osteoclastogenesis inhibitor
STA-21 (STAT-3 inhibitor)Osteoclastogenesis inhibitor
TGF-beta Osteoclastogenesis inhibitor
Alpha2/Beta1 integrin Bone homing and drug vehicles