Research Article
PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women
Table 2
List of PTEN mutations in endometrial samples.
| | Case number | Exon | Nucleotide | Codon | Base change | Predicted effect | Histological diagnosis |
| | 1 | 6 | 540 | 180 | Del G | Stop 181 | Complex hyperplasia |
| | 2 | 7 | 751 | 250 | TGT to CGT | Cys to Arg | Complex hyperplasia |
| | 3 | 8 | 968 | 323 | Del A | Stop 343 | Complex hyperplasia |
| | 4 | 5 | 349–351 | 117 | Ins A | Stop 125 | Atypical complex hyperplasia | | 7 | 691–693 | 231 | Del C | Stop 255 | | 8 | 968 | 323 | Del A | Stop 343 |
| | 5 | 5 | 389 | 130 | CGA to CTA | Arg to Leu | Atypical complex hyperplasia | | 8 | 968 | 323 | Del A | Stop 343 |
| | 6 | 8 | 968 | 323 | Del A | Stop 343 | Endometrioid carcinoma Grade 1 |
| | 7 | 5 | 388 | 130 | CGA to GGA | Arg to Gly | Endometrioid carcinoma Grade 1 |
| | 8 | 5 | 278 | 93 | Del A | Stop 98 | Endometrioid carcinoma Grade 1 |
| | 9 | 8 | 968 | 323 | Del A | Stop 343 | Endometrioid carcinoma Grade 1 |
| | 10 | 5 | 349–351 | 117 | Ins A | Stop 125 | Endometrioid carcinoma Grade 1 | | 8 | 968 | 323 | Del A | Stop 343 |
| | 11 | 5 | 349–351 | 117 | Ins A | Stop 125 | Endometrioid carcinoma Grade 1 | | 8 | 968 | 323 | Del A | Stop 343 |
| | 12 | 5 | 462 | 154 | TTC to TTT | No change | Endometrioid carcinoma Grade 1 | | 8 | 843 | 281 | CCA to CCG | No change |
| | 13 | 5 | 349–351 | 117 | Ins A | Stop 125 | Endometrioid carcinoma Grade 1 |
| | 14 | 2 | 158 | 53 | Ins C | Stop 62 | Endometrioid carcinoma Grade 1 | | 5 | 362 | 121 | GCA to GTA | Ala to Val | | 462 | 154 | TTC to TTT | No change | | 7 | 777 | 259 | CAC to CAT | No change | | 8 | 968 | 323 | Del A | Stop 343 |
| | 15 | 6 | 518 | 173 | CGC to CAC | Arg to His | Endometrioid carcinoma Grade 1 | | 8 | 968 | 323 | Del A | Stop 343 |
| | 16 | 5 | 388 | 130 | CGA to GGA | Arg to Gly | Endometrioid carcinoma Grade 1 |
| | 17 | 3 | 204 | 68 | TAC to TAG | Stop 68 | Endometrioid carcinoma Grade 1 |
| | 18 | 5 | 389 | 130 | CGA to CTA | Arg to Leu | Endometrioid carcinoma Grade 1 |
| | 19 | 5 | 389 | 130 | CGA to CTA | Arg to Leu | Endometrioid carcinoma Grade 1 | | 7 | 691–693 | 231 | Del C | Stop 255 | | 8 | 968 | 323 | Del A | Stop 343 |
| | 20 | 5 | 389 | 130 | CGA to CTA | Arg to Leu | Endometrioid carcinoma Grade 1 |
| | 21 | 5 | 318 | 106 | GAA to GAG | No change | Endometrioid carcinoma Grade 3 |
| | 22 | 1 | 14 | 5 | ATC to AGC | Ile to Ser | Endometrioid carcinoma Grade 3 | | 6 | 511 | 171 | CAG to TAG | Stop 171 | | 8 | 968 | 323 | Del A | Stop 343 |
| | 23 | 5 | 370 | 124 | TGT to GGT | Cys to Gly | Endometrioid carcinoma Grade 3 |
| | 24 | 5 | 389 | 130 | CGA to CCA | Arg to Pro | Endometrioid carcinoma Grade 3 |
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