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Analytical Cellular Pathology
Volume 2015, Article ID 784612, 10 pages
http://dx.doi.org/10.1155/2015/784612
Research Article

Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice

1Departamento de Patologia, Universidade Federal de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil
2Serviço de Patologia, Hospital Universitário de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil
3Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Campus Universitário, Camobi, 97105-900 Santa Maria, RS, Brazil

Received 19 April 2015; Accepted 10 June 2015

Academic Editor: Andrea Stringer

Copyright © 2015 Sônia Cristina Almeida da Luz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tellurium compounds may be cytotoxic to different cells types. Thus, this work evaluated the effect of diphenyl ditelluride ((PhTe)2), an organotellurium commonly used in organic synthesis, on the morphology of liver, kidney, and lung. Adult mice were acutely (a subcutaneous single dose: 250 μmol/kg) or subchronically (one daily subcutaneous dose: 10 or 50 μmol/kg for 7 and 14 days) exposed to (PhTe)2. Afterwards, the histological analyses of liver, kidney, and lungs were performed. Liver histology revealed that the hepatocytes of mice subchronically exposed to (PhTe)2 presented cytoplasmic vacuolization, hydropic degeneration, and hyperchromatic nuclei. Subchronic exposure to 50 μmol/kg (PhTe)2 also caused hepatic necrosis. Microvesicular and macrovesicular steatosis were identified in liver of mice acutely exposed to (PhTe)2. Acute and subchronic intoxication with (PhTe)2 induced changes on epithelial cells of renal tubules, namely, loss of brush border and cytoplasmatic vacuolization. Atrophy and hypertrophy, cast proteinaceous formation, and acute tubular necrosis were also identified in renal tissue. Mice subchronically exposed to 50 μmol/kg (PhTe)2 developed intra-alveolar edema and alveolar wall congestion in some areas of lungs. Acute exposure to (PhTe)2 did not cause histological changes in lungs. Our data show that (PhTe)2 may be considered a histotoxic agent for liver, kidney, and lung.