Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice

Figure 7

Kidney histological analysis of mice exposed acutely to diphenyl ditelluride 250 μmol/kg. Kidney section of control group showing (a) conserved architecture of renal cortex with convoluted tubules outlined for a single layer of cuboidal cells and preserved glomeruli and (b) renal medullar area with collecting tubule of normal morphology. Kidney of diphenyl ditelluride treated mice showing (c) tubules in different stages of compression (arrows), epithelial cells free in tubular lumen; presence of hypertrophic tubules filled with eosinophilic homogeneous substance (cast proteinaceous); (d) presence of tubules containing a single layer of epithelial cells and small vacuoles, presence of tubules filled with eosinophilic homogeneous substance (cast proteinaceous); (e) Kidney section with PAS stain, confirming the presence of cast proteinaceous in hypertrophic tubules (positive PAS stain/detail in 40x) (H&E 10x). The picture is a representation of three independent experiments.

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