Table of Contents Author Guidelines Submit a Manuscript
Analytical Cellular Pathology
Volume 2016, Article ID 3152967, 7 pages
http://dx.doi.org/10.1155/2016/3152967
Research Article

PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus

1University Medical Centre Maribor, Clinic for Internal Medicine, Department for Diabetes and Metabolic Diseases, Maribor, Slovenia
2General Hospital Izola, Department of Internal Medicine, Izola, Slovenia
3General Hospital Slovenj Gradec, Department of Internal Medicine, Slovenj Gradec, Slovenia
4General Hospital Murska Sobota, Department of Internal Medicine, Murska Sobota, Slovenia
5Faculty of Medicine, Institute of Histology and Embryology, University of Ljubljana, Ljubljana, Slovenia

Received 20 September 2016; Accepted 7 December 2016

Academic Editor: Ekaterina A. Ivanova

Copyright © 2016 Matej Završnik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Donate-Correa, E. Martín-Núñez, M. Muros-de-Fuentes, C. Mora-Fernández, and J. F. Navarro-González, “Inflammatory Cytokines in Diabetic Nephropathy,” Journal of Diabetes Research, vol. 2015, Article ID 948417, 9 pages, 2015. View at Publisher · View at Google Scholar
  2. M. Afkarian, M. C. Sachs, B. Kestenbaum et al., “Kidney disease and increased mortality risk in type 2 diabetes,” Journal of the American Society of Nephrology, vol. 24, no. 2, pp. 302–308, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. B. I. Freedman, M. Bostrom, P. Daeihagh, and D. W. Bowden, “Genetic factors in diabetic nephropathy,” Clinical Journal of the American Society of Nephrology, vol. 2, no. 6, pp. 1306–1316, 2007. View at Publisher · View at Google Scholar
  4. T. Wu, K. C. Y. McGrath, and A. K. Death, “Cardiovascular disease in diabetic nephropathy patients: cell adhesion molecules as potential markers?” Vascular Health and Risk Management, vol. 1, no. 4, pp. 309–316, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. J. R. Privratsky and P. J. Newman, “PECAM-1: regulator of endothelial junctional integrity,” Cell and Tissue Research, vol. 355, no. 3, pp. 607–619, 2014. View at Publisher · View at Google Scholar
  6. S. Kondo, E. A. Scheef, N. Sheibani, and C. M. Sorenson, “PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis,” American Journal of Physiology—Cell Physiology, vol. 292, no. 6, pp. C2070–C2083, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Kitazume, R. Imamaki, K. Ogawa, and N. Taniguchi, “Sweet role of platelet endothelial cell adhesion molecule in understanding angiogenesis,” Glycobiology, vol. 24, no. 12, pp. 1260–1264, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. J. R. Privratsky, D. K. Newman, and P. J. Newman, “PECAM-1: conflicts of interest in inflammation,” Life Sciences, vol. 87, no. 3-4, pp. 69–82, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. J. P. Newton, C. D. Buckley, E. Y. Jones, and D. L. Simmons, “Residues on both faces of the first immunoglobulin fold contribute to homophilic binding sites of PECAM-1/CD31,” The Journal of Biological Chemistry, vol. 272, no. 33, pp. 20555–20563, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. M. S. Novinska, B. C. Pietz, T. M. Ellis, D. K. Newman, and P. J. Newman, “The alleles of PECAM-1,” Gene, vol. 376, no. 1-2, pp. 95–101, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Auer, T. Weber, R. Berent, E. Lassnig, G. Lamm, and B. Eber, “Genetic polymorphisms in cytokine and adhesion molecule genes in coronary artery disease,” American Journal of PharmacoGenomics, vol. 3, no. 5, pp. 317–328, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Wei, L. Fang, S. H. Chowdhury et al., “Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with severe coronary artery stenosis in Chinese Singaporean,” Clinical Biochemistry, vol. 37, no. 12, pp. 1091–1097, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Fang, H. Wei, S. H. Chowdhury et al., “Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian Indians,” Indian Journal of Medical Research, vol. 121, no. 2, pp. 92–99, 2005. View at Google Scholar · View at Scopus
  14. Y.-S. Wei, Y. Lan, Y.-G. Liu, L.-Q. Meng, Q.-Q. Xu, and H.-Y. Xie, “Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with ischemic stroke,” DNA and Cell Biology, vol. 28, no. 3, pp. 151–158, 2009. View at Publisher · View at Google Scholar
  15. Y. Song, R. Zhao, L. Long, N. Zhang, and Y. Liu, “Leu125val polymorphism of platelet endothelial cell adhesion molecule-1 is associated with atherosclerotic cerebral infarction in chinese han population,” International Journal of Clinical and Experimental Medicine, vol. 7, no. 12, pp. 5808–5813, 2014. View at Google Scholar · View at Scopus
  16. E. Nadi, M. Hajilooi, D. Babakhani, and A. Rafiei, “Platelet endothelial cell adhesion molecule-1 polymorphism in patients with bronchial asthma,” Iranian Journal of Allergy, Asthma and Immunology, vol. 11, no. 4, pp. 276–281, 2012. View at Google Scholar · View at Scopus
  17. G. Li, Z. L. Han, H. G. Dong, X. Zhang, X. Q. Kong, and X. Jin, “Platelet endothelial cell adhesion molecule 1 gene 125C/G polymorphism is associated with deep vein thrombosis,” Molecular Medicine Reports, vol. 12, no. 2, pp. 2203–2210, 2015. View at Publisher · View at Google Scholar
  18. W. Sun, F.-S. Li, Y.-H. Zhang, X.-P. Wang, and C.-R. Wang, “Association of susceptibility to septic shock with platelet endothelial cell adhesion molecule-1 gene Leu125Val polymorphism and serum sPECAM-1 levels in sepsis patients,” International Journal of Clinical and Experimental Medicine, vol. 8, no. 11, pp. 20490–20498, 2015. View at Google Scholar · View at Scopus
  19. T. Xia, X. Liu, C. J. Du, X. Jin, X. Q. Kong, and G. Li, “Association of leu125Val polymorphisms in the PECAM-1 gene with the risk of coronary heartdisease: a meta-analysis,” International Journal of Clinical and Experimental Medicine, vol. 8, no. 2, pp. 2219–2225, 2015. View at Google Scholar · View at Scopus
  20. K. Kamiuchi, G. Hasegawa, H. Obayashi et al., “Intercellular adhesion molecule-1 (ICAM-1) polymorphism is associated with diabetic retinopathy in Type 2 diabetes mellitus,” Diabetic Medicine, vol. 19, no. 5, pp. 371–376, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Reschner, A. Milutinovic, and D. Petrovič, “The PECAM-1 gene polymorphism—a genetic marker of myocardial infarction,” Central European Journal of Biology, vol. 4, no. 4, pp. 515–520, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. American Diabetes Association, “Diagnosis and classification of diabetes mellitus,” Diabetes Care, vol. 35, supplement 1, pp. S64–S71, 2011. View at Publisher · View at Google Scholar
  23. World Health Organization, “Part 1: diagnosis and clasification of diabetes mellitus: report of a WHO consultation,” in Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications, A. Alwan and H. King, Eds., Word Health Department of Noncommunicable Disease Surveillance, Geneva, Switzerland, 1999. View at Google Scholar
  24. V. Rattan, Y. Shen, C. Sultana, D. Kumar, and V. K. Kalra, “Glucose-induced transmigration of monocytes is linked to phosphorylation of PECAM-1 in cultured endothelial cells,” American Journal of Physiology—Endocrinology and Metabolism, vol. 271, no. 4, part 1, pp. E711–E717, 1996. View at Google Scholar · View at Scopus
  25. V. Rattan, C. Sultana, Y. Shen, and V. K. Kalra, “Oxidant stress-induced transendothelial migration of monocytes is linked to phosphorylation of PECAM-1,” American Journal of Physiology—Endocrinology and Metabolism, vol. 273, no. 3, part 1, pp. E453–E461, 1997. View at Google Scholar · View at Scopus
  26. M. Okouchi, N. Okayama, S. Imai et al., “High insulin enhances neutrophil transendothelial migration through increasing surface expression of platelet endothelial cell adhesion molecule-1 via activation of mitogen activated protein kinase,” Diabetologia, vol. 45, no. 10, pp. 1449–1456, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Nakagawa, T. Kosugi, M. Haneda, C. J. Rivard, and D. A. Long, “Abnormal angiogenesis in diabetic nephropathy,” Diabetes, vol. 58, no. 7, pp. 1471–1478, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Park, T. A. DiMaio, E. A. Scheef, C. M. Sorenson, and N. Sheibani, “PECAM-1 regulates proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactions,” American Journal of Physiology—Cell Physiology, vol. 299, no. 6, pp. C1468–C1484, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. I. A. Hauser, R. Riess, B. Hausknecht, H. Thüringer, and R. B. Sterzel, “Expression of cell adhesion molecules in primary renal disease and renal allograft rejection,” Nephrology Dialysis Transplantation, vol. 12, no. 6, pp. 1122–1131, 1997. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Isome, H. Fujinaka, E. Yaoita et al., “Involvement of endothelial cell adhesion molecules in the development of anti-Thy-1 nephritis,” Experimental Nephrology, vol. 10, no. 5-6, pp. 338–347, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Khan, S. Lakhe-Reddy, J. H. McCarty et al., “Mesangial cell integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1,” American Journal of Pathology, vol. 178, no. 2, pp. 609–620, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. K. Cheung, L. Ma, G. Wang et al., “CD31 signals confer immune privilege to the vascular endothelium,” Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 43, pp. E5815–E5824, 2015. View at Publisher · View at Google Scholar
  33. H. J. Baelde, M. Eikmans, P. P. Doran, D. W. P. Lappin, E. De Heer, and J. A. Bruijn, “Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy,” American Journal of Kidney Diseases, vol. 43, no. 4, pp. 636–650, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. R. S. Goodman, C. M. Kirton, G. J. Oostingh et al., “PECAM-1 polymorphism affects monocyte adhesion to endothelial cells,” Transplantation, vol. 85, no. 3, pp. 471–477, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. J. T. Bazzaz, M. M. Amoli, V. Pravica, B. Larijani, and I. V. Hutchinson, “PECAM-1 (CD31) gene polymorphisms in type 1 diabetes and its microangiopathic complications,” Journal of Diabetes and Metabolic Disorders, vol. 10, pp. 1–13, 2011. View at Google Scholar
  36. T. Yoshida, K. Kato, K. Yokoi et al., “Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus,” International Journal of Molecular Medicine, vol. 23, no. 4, pp. 529–537, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. T. Yoshida, K. Kato, K. Yokoi et al., “Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors,” International Journal of Molecular Medicine, vol. 23, no. 6, pp. 785–792, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Fornasa, E. Groyer, M. Clement et al., “TCR stimulation drives cleavage and shedding of the ITIM receptor CD31,” Journal of Immunology, vol. 184, no. 10, pp. 5485–5492, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Goldberger, K. A. Middleton, J. A. Oliver et al., “Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form,” The Journal of Biological Chemistry, vol. 269, no. 25, pp. 17183–17191, 1994. View at Google Scholar · View at Scopus
  40. S. Kathiresan, C. Newton-Cheh, and R. E. Gerszten, “On the interpretation of genetic association studies,” European Heart Journal, vol. 25, no. 16, pp. 1378–1381, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Kussmann, M. J. Morine, J. Hager, B. Sonderegger, and J. Kaput, “Perspective: a systems approach to diabetes research,” Frontiers in Genetics, vol. 4, article 205, 2013. View at Publisher · View at Google Scholar
  42. Y. Doring, H. Noels, and C. Weber, “The use of high-throughput technologies to investigate vascular inflammation and atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 2, pp. 182–195, 2012. View at Publisher · View at Google Scholar
  43. J. R. Heath, “Nanotechnologies for biomedical science and translational medicine,” Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 47, pp. 14436–14443, 2015. View at Publisher · View at Google Scholar