Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas

Table 3

The cell counting methods used to determine the labeling index. The kappa coefficient was obtained by comparing each method. The manual (manual scoring and DM scoring) and advanced ImmunoRatio (IRA scoring and IRpA scoring) methods showed substantial kappa coefficients. Italic text indicate substantial kappa coefficient and bold text indicates a significance level of .

Technique versus	Manual scoring	DM scoring	IRA scoring	IRpA scoring	IRB scoring	IRpB scoring
Manual scoring	N/A	0.698	0.026	0.024	0.026
DM scoring	0.698	N/A			0.023
IRA scoring	0.026		N/A	0.788
IRpA scoring	0.024		0.788	N/A
IRB scoring	0.026	0.023			N/A	0.055
IRpB scoring					0.055	N/A