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Analytical Cellular Pathology
Volume 2017 (2017), Article ID 5108653, 9 pages
Review Article

The Recent Advances on Liver Cancer Stem Cells: Biomarkers, Separation, and Therapy

1Taizhou People’s Hospital Affiliated to Nantong University, Taizhou, Jiangsu 225300, China
2School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, Hubei 430000, China

Correspondence should be addressed to Mei Lin

Received 21 March 2017; Accepted 5 July 2017; Published 27 July 2017

Academic Editor: Neng Wang

Copyright © 2017 Yanhong Xiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As the third major reason of mortality related to cancer in the world, liver cancer is also the fifth most frequent cancer. Unluckily, a majority of patients succumb and relapse though many progresses have been made in detection and therapy of liver cancer. It has been put forward that in liver cancer, cancer stem cells (CSCs) hold main responsibility for the formation, invasion, metastasis, and recurrence of tumor. Strategies that are intended to target liver CSCs are playing a more and more significant role in supervising the development of liver cancer treatment and assessing new therapeutic methods. Herein, a brief review about molecule markers, signal pathways, separation, and treatment on liver cancer stem cells (LCSCs) is provided in this paper.