Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats
Expression of KYNA-related genes in rat and human liver tissue. (a) Expression of genes coding for α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits (Gria1, Gria2, Gria3, and Gria4), kainate receptor subunits (Grik1, Grik2, Grik3, Grik4, and Grik5), N-methyl-D-aspartate (NMDA) receptor subunits (Grin1, Grin2a, Grin2b, Grin2c, Grin2d, Grin3a, and Grin3b), α7 nicotinic acetylcholine receptor (Chrna7), and aryl hydrocarbon receptor (Ahr) in rat liver tissue (). There was no available data on G protein-coupled receptor 35 (Gpr35) expression. (b) Expression of Aadat, Kyat3, and Got2 genes coding for kynurenine aminotransferases (KATs) in rat liver tissue (). No probes were available for Kyat1 gene within the selected array. Data on rat gene expression were retrieved from previously described [26–37] microarray experiments deposited in GEO (accession numbers: GSE5350, GSE5509, GSE8880, GSE10408, GSE11097, GSE11097, GSE10411, GSE10015, GSE12196, GSE14712, GSE57822, GSE73500) and ArrayExpress (accession numbers: E-MTAB-799, E-MTAB-800) databases. (c) Expression profile of human orthologues of the rat genes coding for KYNA-related receptors (). (d) Expression of human orthologues of KAT-coding rat genes (). Data on expression of the genes of interest in human liver tissues were extracted from previously described [38–44] microarray-profiling experiments available at the GEO repository (accession numbers: GSE23343, GSE11190, GSE3526, GSE37031, GSE55092, GSE28619, GSE7307, GSE43346).
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