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Analytical Cellular Pathology
Volume 2018, Article ID 2678924, 7 pages
Research Article

Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts

1Banat’s University of Agricultural Sciences and Veterinary Medicine, “King Michael I of Romania” from Timisoara, Calea Aradului No. 119, 300645 Timişoara, Romania
2University of Medicine and Pharmacy “Victor Babes” Timisoara, Eftimie Murgu Square No. 2, 300041 Timişoara, Romania

Correspondence should be addressed to Corina Danciu; or.tfmu@uicnad.aniroc

Received 7 July 2017; Accepted 18 October 2017; Published 10 January 2018

Academic Editor: Consuelo Amantini

Copyright © 2018 Ersilia Alexa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study aimed to investigate the phytochemical composition of Mentha × piperita L. (MP) and Lavandula angustifolia Mill. (LA) extracts in terms of hydroxycinnamic acid (HCAs) content, in particular, caffeic (CA), p-cumaric (CU), ferulic (FE), and rosmarinic (RS) acids using LC-MS. Also, the in vitro antimicrobial effect against Staphylococcus aureus and the antiproliferative activity against two cancerous cell lines (A375 and MDA-MB-231) using the MTT assay were tested. The extracts were prepared using aromatic water which resulted from the extraction of oils from plants as extraction medium, with/without acid. The results showed that RS and FE represent the majority of HCAs compounds; the highest content of FE is found in LA (7.47 mg·g–1d.m.), and the maximum content of RS in MP (6.36 mg·g–1d.m.). Regarding the antimicrobial effect against Staphylococcus aureus, the two extracts showed a simulative role on the growth rate of Staphyloccocus aureus, but a slightly inhibitory effect (69.12%) can be attributed to the acidic environment. In terms of biological activity against MDA-MB-231 breast carcinoma cell line, and A375 human melanoma cell line, at the highest employed concentration, 150 μg·mL–1, the tested extracts present a weak antiproliferative effect.