High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis

Table 1

Expression of actin-binding proteins cofilin and N-WASP in human laryngeal cancer in relation to clinical and pathological parameters.

		Cofilin cytoplasmic expression				value	Cofilin nuclear expression				value	N-WASP expression				value
		Low; (n, %)		High; (n, %)			Low; (n, %)		High; (n, %)			Low; (n, %)		High; (n, %)
Age	≤60	18	51.4%	17	48.6%	0.825	28	80.0%	7	20.0%	0.155	14	40.0%	21	60.0%	0.782
	>60	20	54.1%	17	45.9%		24	64.9%	13	35.1%		16	43.2%	21	56.8%
Location	Glottis	21	48.8%	22	51.2%	0.698	32	74.4%	11	25.6%	0.729	15	34.9%	28	65.1%	0.115
	Supraglottis	16	59.3%	11	40.7%		19	70.4%	8	29.6%		15	55.6%	12	44.4%
	Subglottis	1	50.0%	1	50.0%		1	50.0%	1	50.0%		0	0.0%	2	100.0%
Grade	Grade I	7	53.8%	6	46.2%	0.981	10	76.9%	3	23.1%	0.634	2	15.4%	11	84.6%	0.031
	Grade II	26	53.1%	23	46.9%		36	73.5%	13	26.5%		21	42.9%	28	57.1%
	Grade III	5	50.0%	5	50.0%		6	60.0%	4	40.0%		7	70.0%	3	30.0%
N	No	28	52.8%	25	47.2%	0.988	36	67.9%	17	32.1%	0.177	21	39.6%	32	60.4%	0.560
	N1–3	10	52.6%	9	47.4%		16	84.2%	3	15.8%		9	47.4%	10	52.6%
Stage	I	1	100.0%	0	0.0%		1	100.0%	0	0.0%		0	0.0%	1	100.0%
	II	3	75.0%	1	25.0%		3	75.0%	1	25.0%		3	75.0%	1	25.0%
	III	14	56.0%	11	44.0%	0.510	18	72.0%	7	28.0%	0.960	13	52.0%	12	48.0%	0.135
	IV	20	47.6%	22	52.4%		30	71.4%	12	28.6%		14	33.3%	28	66.7%

Statistical analyses were performed by nonparametric tests, and was considered statistically significant. Lymph node (N) metastasis and stage were determined based on TNM, 7th edition [33].