Research Article
DNA Repair Gene XRCC1 and XPD Polymorphisms and Gastric Cancer Risk: A Case-Control Study Outcome from Kashmir, India
Table 3
Independent and combined genotypic distribution of XPD and XRCC1 in gastric cancer cases and matched controls.
| | Genotypes | Cases n (%) | Controls n (%) | Unadjusted OR1 (95% CI) | Adjusted10 OR (95% CI2) |
| | Total | 180 (100) | 200 (100) | — | — | | XRCC1 399 | | | | | | Arg/Arg3 | 56 (31.11) | 47 (23.50) | Referent | Referent | | Arg/Gln4 | 92 (51.11) | 124 (62.00) | 0.65 (0.41–1.03) | 0.95 (0.32–2.84) | | Gln/Gln5 | 32 (17.78) | 29 (14.50) | 0.99 (0.52–1.88) | 1.56 (0.32–7.82) | | Arg/Gln + Gln/Gln | 124 (68.89) | 153 (76.50) | 0.71 (0.46–1.11) | 1.01 (0.34–3.01) | | XPD 751 | | | | | | Lys/Lys6 | 107 (59.44) | 114 (57.00) | Referent | Referent | | Lys/Gln7 | 49 (27.22) | 55 (27.50) | 0.90 (0.57–1.41) | 1.40 (0.45–4.32) | | Gln/Gln8 | 24 (13.33) | 31 (15.50) | 0.82 (0.43–1.53) | 0.46 (0.10–2.19) | | Lys/Gln + Gln/Gln | 73 (40.56) | 86 (43.0) | 0.87 (0.59–1.29) | 0.95 (0.40–2.27) | | Combined genotypes9 ( interaction = 0.793 and SE = 0.568) | | | | | | XRCC1 Arg/Arg + XPD Lys/Lys | 32 (17.78) | 25 (12.50) | Referent | Referent | | XRCC1 Arg/Arg + XPD (Lys/Gln + Gln/Gln) | 24 (13.33) | 22 (11.00) | 0.79 (0.35–1.74) | 2.72 (0.28–26.78) | | XRCC1 (Arg/Gln + Gln/Gln) + XPD Lys/Lys | 75 (41.67) | 89 (44.50) | 0.67 (0.35–1.26) | 2.09 (0.32–13.61) | | XRCC1 (Arg/Gln + Gln/Gln) + XPD (Lys/Gln + Gln/Gln) | 49 (27.22) | 64 (32.00) | 0.60 (0.32–1.12) | 1.31 (0.25–6.82) |
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1OR = odds ratio. ORs (95% CIs) were obtained from conditional logistic regression models. 2Confidence interval. 3XRCC1 wild genotype. 4XRCC1 heterozygous genotype. 5XRCC1 mutant genotype. 6XPD wild genotype. 7XPD heterozygous genotype. 8XPD mutant genotype. 9Genotype effects of both genes. 10Adjusted ORs (95% CIs) were obtained in conditional logistic regression models with adjustment for residence, gender, family history, chillies, X-ray, smoking, and dried foods.
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