Erythrocyte Senescence in a Model of Rat Displaying Hutchinson-Gilford Progeria Syndrome

Figure 3

Activity of different ionic pumps in erythrocyte membrane and effect of DHT treatment. The values represent the mean ± SD of eight different groups. (a) Age-dependent decrease in NKA activity was noted with significantly () lower activity in erythrocyte of old control rats compared to that of corresponding young control rats. Induction of progeria in rats significantly () reduced the NKA activity compared to the corresponding age-matched young control group and the value of young erythrocytes approached that of the old control group with nonsignificant difference. However, old erythrocyte of the old control group was significantly lower compared to that of the progeroid group with overall less significant difference in NKA activity of the progeroid group and the old control group. (b) There was a significant () decrease in PMCA activity in the erythrocyte membrane progeroid group compared to the age-matched control rats; however, the activity was significantly () higher than the old control groups. (c) Increase in NHE activity is noted as function of organismal aging with significantly () higher activity observed for old control rats compared to the young control rats. Induced progeria significantly () increased the overall NHE activity of erythrocytes compared to the young control group; however, nonsignificant difference in NHE activity of young erythrocytes of the progeroid group and that of the young control group was found. Young erythrocytes of each group however showed an increased NHE activity indicating decreased NHE activity with erythrocyte aging.

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