Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 Numerical Aberrations in Oral Squamous Cell Carcinomas
Table 4
Variables included in the multivariate Cox regression analysis of overall survival and disease-free survival.
Factor
Group
N
value
Exp (β)
95% CI of Exp (β)
Overall survival
Tumour size
T1
21
0.659
1
T2
27
0.263
0.223
0.016–3.08
T3
6
0.368
0.237
0.01–5.445
T4
11
0.217
0.220
0.2–2.437
Nodal status
N0
45
0.716
1
N1
11
0.466
1.672
0.42–6.658
N2
9
0.462
1.909
0.341–10.678
Stage
I
20
<0.001
1
II
20
0.922
1.063
0.315–3.58
III
11
0.041
3.548
1.052–11.963
IV
14
<0.001
14.309
4.641–44.121
Perineural permeation
Absent
54
0.306
1
Present
11
1.654
0.631–4.339
Cyclin A2
<25%
40
0.031
1
≥25%
25
2.397
1.085–5.295
Disease-free survival
Tumour size
T1
22
0.407
1
T2
27
0.783
0.691
0.05–9.568
T3
6
0.426
0.281
0.012–6.396
T4
9
0.234
0.249
0.025–2.455
Nodal status
N0
46
0.484
1
N1
10
0.367
0.479
1.1–5.362
N2
8
0.232
0.313
1.821–19.42
Stage
I
21
<0.001
1
II
20
0.232
1.741
0.7018–4.321
III
11
0.054
2.666
0.982–7.237
IV
12
<0.001
9.767
3.727–25.599
Histological grade
G1
32
0.006
1
G2
28
0.028
2.428
1.100–5.362
G3
4
0.003
5.947
1.821–19.420
Variables included in multivariable Cox regression analysis for OS: tumour size, nodal status, clinical stage, perineural permeation, and cyclin A2 expression, and for DFS: tumour size, nodal status, clinical stage, and tumour histological grade.
