High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma

Table 2

Cox proportional regression analyses of variables affecting the local recurrence-free survival (LRFS) in NPC patients.

Variables	Subsets	Local recurrence-free survival
		Univariate analysis		Multivariate analysis
		HR (95% CI)	value	HR (95% CI)	value
HLA-F expression	High vs. low and moderate	3.80 (1.43–10.11)	0.008	3.87 (1.29–11.58)	0.016
Gender	Male vs. female	0.41 (0.10–1.66)	0.213
Age (years)	<54 vs. ≥54	0.29 (0.06–1.46)	0.133
Tumour differentiation	Undifferentiated vs. differentiated	2.01 (0.50–8.07)	0.325
Tumour stage	T1 + T2 vs. T3 + T4	5.36 (1.25–23.06)	0.024	4.31 (1.01–18.46)	0.049
Lymph node status	N0 vs. N1–3	3.04 (0.37–24.72)	0.299
TNM stage	I + II vs. III + IV	1.76 (0.35–8.75)	0.490

Abbreviation: HR: hazard ratio; CI: confidence interval; HLA-F: human leukocyte antigen F; TNM: tumour node metastasis.