Analytical Cellular Pathology / 2018 / Article / Tab 1

Review Article

Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury

Table 1

Role of the methyl-binding domain protein family.

MBD familyBinding activityImplicationReference

MeCP2Binds to methyl CpG with an adjacent stretch of AT-rich nucleotideRepression of transcriptional activity[80]
MBD1Binds to methyl CpG via methyl-binding domainGene silencing during DNA replication[75]
MBD2Binds to methyl CpGRepression of transcriptional activity[85]
MBD3Low binding/incapable of binding to methyl CpGSubunit of NuRD corepressor complex and acts as a transcriptional repressor[86]
MBD4Binds to methyl CpG and T:G mismatches at methyl CpG sitesCatalyses the removal of T and U paired with G within CpG sites[87]

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