Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury

Table 1

Role of the methyl-binding domain protein family.

MBD family	Binding activity	Implication	Reference
MeCP2	Binds to methyl CpG with an adjacent stretch of AT-rich nucleotide	Repression of transcriptional activity	[80]
MBD1	Binds to methyl CpG via methyl-binding domain	Gene silencing during DNA replication	[75]
MBD2	Binds to methyl CpG	Repression of transcriptional activity	[85]
MBD3	Low binding/incapable of binding to methyl CpG	Subunit of NuRD corepressor complex and acts as a transcriptional repressor	[86]
MBD4	Binds to methyl CpG and T:G mismatches at methyl CpG sites	Catalyses the removal of T and U paired with G within CpG sites	[87]