Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features

Table 5

Univariate analysis of disease-free survival in patients with early-stage adult granulosa cell tumors.

Features		Number of documented recurrence	% 5-year DFS	Log-rank test (-test) value
Age (years)
≤55 y	18	2	94%	0.624
>55 y	14	2	83.5%
FIGO substage
IA	26	1	100%	0.0002
IC	6	3	42%
Surgery
Radical surgery	25	1	95%	0.004
Fertility surgery	7	3	71%
Tumor size
<10 cm	23	3	90.5%	0.860
≥10 cm	7	1	83.5%
Dominant growth pattern AGCT
Diffuse	14	4	76%	0.012
Others	18	0	100%
Grade of cytologic atypia
1	15	0	100%	0.032
2 and 3	17	4	79.5%
Mitotic index
<4	17	2	94%	0.736
≥4	15	2	83.5%
LVSI
Negative	22	1	95%	0.058
Positive	10	3	78%
Necrosis
Absent	26	3	92%	0.609
Present	6	1	80%
Hemorrhage
Absent	23	1	95%	0.022
Present	9	3	76%
Prominent fibrothecomatous component
Absent	22	2	96%	0.396
Present	10	2	77%