Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma

Table 5

Univariate and multivariate analysis of survival in 80 patients with OC.

Variables	Univariate analysis			Multivariate analysis^a
	HR	95% CI		HR	95% CI
Histology
Epithelial vs. other	1.690	0.798-3.852	0.171	—	—	—
FIGO Stage
I-II vs. III-IV	2.349	1.143-4.826	0.020	1.004	0.319-3.164	0.994
Grade
G1 vs. G2-G3	2.491	1.183-5.244	0.016	2.529	0.755-8.472	0.133
Node status
Positive vs. negative	1.700	0.816-3.540	0.156	—	—	—
Omentum metastasis
Positive vs. negative	0.868	0.428-1.761	0.695	—	—	—
Organ metastasis
Positive vs. negative	1.168	0.560- 2.438	0.678	—	—	—
Ascites
≥500 ml vs. <500 ml	2.175	1.072-4.411	0.031	1.715	0.489-6.016	0.400
Platinum resistance
Resistant vs. sensitive	2.675	1.263-5.663	0.010	1.861	0.510-6.787	0.347
FOLR1-positive expression alone
Positive vs. negative	0.824	0.394-1.721	0.606	—	—	—
DHFR-positive expression alone
Positive vs. negative	1.410	0.720-2.761	0.316	—	—	—
MTRR-positive expression alone
Positive vs. negative	2.334	1.066-5.110	0.034	1.444	0.607-3.432	0.406

Notes: ^aBackward Wald test was used for variables screened. was chosen as a criterion for significance. HR: hazard ratio; CI: 95% confidence interval. Metastasis to any one of liver, lung, brain, and spleen.