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Analytical Cellular Pathology
Volume 2019, Article ID 1575031, 9 pages
https://doi.org/10.1155/2019/1575031
Research Article

ILF2 Directly Binds and Stabilizes CREB to Stimulate Malignant Phenotypes of Liver Cancer Cells

1Department of Experiment Center, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China
2Department of Pharmacy, Changhai Hospital of Shanghai, 200433, China
3Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai 200072, China
4People’s Hospital of Pudong New District of Shanghai City, No. 490, South Chuanhuan Road, Shanghai 201200, China
5Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China

Correspondence should be addressed to Kai Li; moc.621@81447iakil and Yanfeng Xu; moc.621@ux_fy

Hui Du and Yun Le contributed equally to this work.

Received 21 July 2018; Revised 12 October 2018; Accepted 20 October 2018; Published 10 February 2019

Academic Editor: Consuelo Amantini

Copyright © 2019 Hui Du et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. A. Farazi and R. A. DePinho, “Hepatocellular carcinoma pathogenesis: from genes to environment,” Nature Reviews Cancer, vol. 6, no. 9, pp. 674–687, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Forner, J. M. Llovet, and J. Bruix, “Hepatocellular carcinoma,” The Lancet, vol. 379, no. 9822, pp. 1245–1255, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. D. B. Shankar, J. C. Cheng, K. Kinjo et al., “The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia,” Cancer Cell, vol. 7, no. 4, pp. 351–362, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Li, J. An, M. Wu et al., “LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2,” Oncotarget, vol. 6, no. 29, pp. 27847–27864, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Hou, X. Cui, Y. Liu et al., “Positive feedback regulation between microRNA-132 and CREB in spinal cord contributes to bone cancer pain in mice,” European Journal of Pain, vol. 20, no. 8, pp. 1299–1308, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. X. Xiao, B. X. Li, B. Mitton, A. Ikeda, and K. M. Sakamoto, “Targeting CREB for cancer therapy: friend or foe,” Current Cancer Drug Targets, vol. 10, no. 4, pp. 384–391, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Tan, S. Wang, L. Zhu et al., “cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 39, pp. 15805–15810, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Zhuang, X. Meng, Y. Li et al., “Cyclic AMP responsive element-binding protein promotes renal cell carcinoma proliferation probably via the expression of spindle and kinetochore-associated protein 2,” Oncotarget, vol. 7, no. 13, pp. 16325–16337, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. H. S. Seo, D. D. Liu, B. N. Bekele et al., “Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non-small cell lung cancer,” Cancer Research, vol. 68, no. 15, pp. 6065–6073, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Zhao, L. Shi, D. Qiu, H. Hu, and P. N. Kao, “NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function,” Experimental Cell Research, vol. 305, no. 2, pp. 312–323, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Cheng, X. Jiang, C. Ding et al., “Expression and critical role of interleukin enhancer binding factor 2 in hepatocellular carcinoma,” International Journal of Molecular Sciences, vol. 17, no. 8, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. Q. Huang, X. He, X. Qiu et al., “Expression of NF45 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth,” Tumour Biology, vol. 35, no. 10, pp. 10149–10157, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Ni, G. Mao, Q. Xue et al., “Upregulated expression of ILF2 in non-small cell lung cancer is associated with tumor cell proliferation and poor prognosis,” Journal of Molecular Histology, vol. 46, no. 4-5, pp. 325–335, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Ni, J. Zhu, J. Zhang et al., “Expression and clinical role of NF45 as a novel cell cycle protein in esophageal squamous cell carcinoma (ESCC),” Tumour Biology, vol. 36, no. 2, pp. 747–756, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. W. E. Haskins, S. Eedala, Y. L. Avinash Jadhav, M. S. Labhan, V. C. Pericherla, and E. J. Perlman, “Insights on neoplastic stem cells from gel-based proteomics of childhood germ cell tumors,” Pediatric Blood & Cancer, vol. 58, no. 5, pp. 722–728, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Y. Lee, K. Q. McKinney, S. Ghosh et al., “Subcellular tissue proteomics of hepatocellular carcinoma for molecular signature discovery,” Journal of Proteome Research, vol. 10, no. 11, pp. 5070–5083, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Wang, H. Wang, Y. Zhang et al., “Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer,” Cellular Signalling, vol. 26, no. 5, pp. 1048–1059, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Qiao, X. Zhang, Y. Zhang et al., “High glucose stimulates tumorigenesis in hepatocellular carcinoma cells through AGER-dependent O-GlcNAcylation of c-Jun,” Diabetes, vol. 65, no. 3, pp. 619–632, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Zhang, F. Sun, Y. Qiao et al., “TFCP2 is required for YAP-dependent transcription to stimulate liver malignancy,” Cell Reports, vol. 21, no. 5, pp. 1227–1239, 2017. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Wang, J. S. Park, Y. Wei et al., “TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPα function,” Molecular Cell, vol. 51, no. 2, pp. 211–225, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. X. Zhang, Y. Qiao, Q. Wu et al., “The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis,” Nature Communications, vol. 8, article 15280, 2017. View at Publisher · View at Google Scholar · View at Scopus
  22. W. J. du Toit, K. Lisjak, M. Stander, and D. Prevoo, “Using LC-MSMS to assess glutathione levels in South African white grape juices and wines made with different levels of oxygen,” Journal of Agricultural and Food Chemistry, vol. 55, no. 8, pp. 2765–2769, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Bürck, A. Mund, J. Berscheminski et al., “KAP1 is a host restriction factor that promotes human adenovirus E1B-55K SUMO modification,” Journal of Virology, vol. 90, no. 2, pp. 930–946, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. E. S. Sokol, Y. X. Feng, D. X. Jin et al., “SMARCE1 is required for the invasive progression of in situ cancers,” Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 16, pp. 4153–4158, 2017. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Williams, R. J. Schneider, and S. Jamal, “Akt and PI3K-dependent but CREB-independent upregulation of MCAM by endothelin-3 in human melanocytes,” Melanoma Research, vol. 24, no. 4, pp. 404–407, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Wang, X. Liu, H. Wu et al., “CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer,” Nucleic Acids Research, vol. 38, no. 16, pp. 5366–5383, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. S. W. Schubert, A. Abendroth, K. Kilian et al., “bZIP-type transcription factors CREB and OASIS bind and stimulate the promoter of the mammalian transcription factor GCMa/Gcm1 in trophoblast cells,” Nucleic Acids Research, vol. 36, no. 11, pp. 3834–3846, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Dahal, T. O. C. Kwan, S. L. Shammas, and J. Clarke, “pKID binds to KIX via an unstructured transition state with nonnative interactions,” Biophysical Journal, vol. 113, no. 12, pp. 2713–2722, 2017. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Wang, L. Ma, W. Weng et al., “Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer,” Hepatology, vol. 58, no. 3, pp. 1011–1020, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Zhang, Q. Wang, N. Zhu et al., “Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIPL and MKP-1, thereby antagonizing UV-induced apoptosis,” Cell Death and Differentiation, vol. 15, no. 10, pp. 1654–1662, 2008. View at Publisher · View at Google Scholar · View at Scopus