Kaempferol Promotes Apoptosis While Inhibiting Cell Proliferation via Androgen-Dependent Pathway and Suppressing Vasculogenic Mimicry and Invasion in Prostate Cancer

Figure 4

Kaempferol inhibited the AR activation in HEK293 and LNCaP cells. (a) In HEK293 cells, HF inhibited DHT-induced activation of AR by 72.46%. Kaempferol inhibited the AR activation by 33.53% at 5 μM, 47.90% at 10 μM, and 67.66% at 15 μM. (b) In LNCaP cells, HF inhibited DHT-induced activation of AR by 72.13%. Kaempferol inhibited the AR activation by 37.19% at 5 μM, 58.40% at 10 μM, and 70.64% at 15 μM (). , compared with cells without kaempferol, DHT, and HF.

(a)

(b)