Identification and Verification of the Main Differentially Expressed Proteins in Gastric Cancer via iTRAQ Combined with Liquid Chromatography-Mass Spectrometry

Table 2

The top 50 proteins with downregulation folds less than 0.8-fold.

n	Accession	Description	Down fold	value
1	O60844	Zymogen granule membrane protein 16 OS=Homo sapiens GN=ZG16 PE=1 SV=2 (ZG16_HUMAN)	0.198959	3.21-19
2	E1CKY7	Protein phosphatase 1 regulatory subunit 12B OS=Homo sapiens GN=sm-M20 PE=1 SV=1 (E1CKY7_HUMAN)	0.254236	2.81-14
3	Q9BYX7	Putative beta-actin-like protein 3 OS=Homo sapiens GN=POTEKP PE=5 SV=1 (ACTBM_HUMAN)	0.260689	8.13-14
4	P51911	Calponin-1 OS=Homo sapiens GN=CNN1 PE=1 SV=2 (CNN1_HUMAN)	0.262319	1.06-13
5	B7Z9B7	cDNA FLJ54732, moderately similar to sorbin and SH3 domain-containing protein 1 OS=Homo sapiens PE=2 SV=1 (B7Z9B7_HUMAN)	0.315502	1.42-10
6	B4E1Q7	cDNA FLJ57294, highly similar to lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) OS=Homo sapiens PE=2 SV=1 (B4E1Q7_HUMAN)	0.339832	1.93-09
7	Q9BTA4	Epididymis secretory protein Li 286 (fragment) OS=Homo sapiens GN=HEL-S-286 PE=2 SV=1 (Q9BTA4_HUMAN)	0.342304	2.47-09
8	A5Z217	Mutant desmin OS=Homo sapiens PE=2 SV=1 (A5Z217_HUMAN)	0.382163	8.56-08
9	A5A3E0	POTE ankyrin domain family member F OS=Homo sapiens GN=POTEF PE=1 SV=2 (POTEF_HUMAN)	0.387963	1.35-07
10	Q96JG9	Zinc finger protein 469 OS=Homo sapiens GN=ZNF469 PE=2 SV=3 (ZN469_HUMAN)	0.395397	2.38-07
11	P08217	Chymotrypsin-like elastase family member 2A OS=Homo sapiens GN=CELA2A PE=1 SV=1 (CEL2A_HUMAN)	0.398866	3.08-07
12	P07098	Gastric triacylglycerol lipase OS=Homo sapiens GN=LIPF PE=1 SV=1 (LIPG_HUMAN)	0.405473	4.96-07
13	B7Z6U8	cDNA FLJ53665, highly similar to four and a half LIM domains protein 1 OS=Homo sapiens PE=2 SV=1 (B7Z6U8_HUMAN)	0.408392	6.09-07
14	P12277	Creatine kinase B-type OS=Homo sapiens GN=CKB PE=1 SV=1 (KCRB_HUMAN)	0.409014	6.36-07
15	P0CG38	POTE ankyrin domain family member I OS=Homo sapiens GN=POTEI PE=3 SV=1 (POTEI_HUMAN)	0.409772	6.71-07
16	B7Z7M8	cDNA FLJ60950, highly similar to hydroxymethylglutaryl-CoA synthase, mitochondrial (EC 2.3.3.10) OS=Homo sapiens PE=2 SV=1 (B7Z7M8_HUMAN)	0.419918	1.33-06
17	P35749	Myosin-11 OS=Homo sapiens GN=MYH11 PE=1 SV=3 (MYH11_HUMAN)	0.420775	1.41-06
18	O15061	Synemin OS=Homo sapiens GN=SYNM PE=1 SV=2 (SYNEM_HUMAN)	0.430091	2.57-06
19	P68032	Actin, alpha cardiac muscle 1 OS=Homo sapiens GN=ACTC1 PE=1 SV=1 (ACTC_HUMAN)	0.437479	4.06-06
20	P26678	Cardiac phospholamban OS=Homo sapiens GN=PLN PE=1 SV=1 (PPLA_HUMAN)	0.440292	4.81-06
21	Q15124	Phosphoglucomutase-like protein 5 OS=Homo sapiens GN=PGM5 PE=1 SV=2 (PGM5_HUMAN)	0.442845	5.60-06
22	B4DTX5	cDNA FLJ60072, highly similar to Homo sapiens sorbin and SH3 domain containing 1 (SORBS1), transcript variant 6, mRNA OS=Homo sapiens PE=2 SV=1 (B4DTX5_HUMAN)	0.444007	6.00-06
23	B3KW93	Sodium/potassium-transporting ATPase subunit alpha OS=Homo sapiens PE=2 SV=1 (B3KW93_HUMAN)	0.446979	7.14-06
24	F8VPF3	Myosin light polypeptide 6 (fragment) OS=Homo sapiens GN=MYL6 PE=1 SV=1 (F8VPF3_HUMAN)	0.448822	7.94-06
25	Q9NR12	PDZ and LIM domain protein 7 OS=Homo sapiens GN=PDLIM7 PE=1 SV=1 (PDLI7_HUMAN)	0.455034	1.13-05
26	Q01995	Transgelin OS=Homo sapiens GN=TAGLN PE=1 SV=4 (TAGL_HUMAN)	0.456778	1.24-05
27	A0A024R5W6	Tropomyosin 1 (alpha), isoform CRA_a OS=Homo sapiens GN=TPM1 PE=3 SV=1 (A0A024R5W6_HUMAN)	0.458474	1.37-05
28	Q63ZY3	KN motif and ankyrin repeat domain-containing protein 2 OS=Homo sapiens GN=KANK2 PE=1 SV=1 (KANK2_HUMAN)	0.461142	1.58-05
29	E9PIE4	Mitochondrial carrier homolog 2 (fragment) OS=Homo sapiens GN=MTCH2 PE=1 SV=7 (E9PIE4_HUMAN)	0.462079	1.66-05
30	Q16853	Membrane primary amine oxidase OS=Homo sapiens GN=AOC3 PE=1 SV=3 (AOC3_HUMAN)	0.465486	2.00-05
31	Q15746	Myosin light chain kinase, smooth muscle OS=Homo sapiens GN=MYLK PE=1 SV=4 (MYLK_HUMAN)	0.466825	2.14-05
32	B3KUD6	cDNA FLJ39634 fis, clone SMINT2002689, highly similar to SMOOTHELIN OS=Homo sapiens PE=2 SV=1 (B3KUD6_HUMAN)	0.467199	2.19-05
33	A0A024R5N4	WD repeat domain 71, isoform CRA_a OS=Homo sapiens GN=WDR71 PE=4 SV=1 (A0A024R5N4_HUMAN)	0.467661	2.24-05
34	P68133	Actin, alpha skeletal muscle OS=Homo sapiens GN=ACTA1 PE=1 SV=1 (ACTS_HUMAN)	0.467865	2.26-05
35	K7EM16	Vasodilator-stimulated phosphoprotein (fragment) OS=Homo sapiens GN=VASP PE=1 SV=1 (K7EM16_HUMAN)	0.471806	2.78-05
36	B4DWU6	cDNA FLJ51361, highly similar to keratin, type II cytoskeletal 6A OS=Homo sapiens PE=2 SV=1 (B4DWU6_HUMAN)	0.474248	3.15-05
37	Q14315	Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 (FLNC_HUMAN)	0.478864	3.98-05
38	O75795	UDP-glucuronosyltransferase 2B17 OS=Homo sapiens GN=UGT2B17 PE=1 SV=1 (UDB17_HUMAN)	0.486547	5.80-05
39	B2RTX2	Palladin, cytoskeletal associated protein OS=Homo sapiens GN=PALLD PE=2 SV=1 (B2RTX2_HUMAN)	0.491737	7.42-05
40	G3 V144	SH3 and PX domain-containing protein 2B OS=Homo sapiens GN=SH3PXD2B PE=1 SV=1 (G3 V144_HUMAN)	0.492826	7.81-05
41	Q05682	Caldesmon OS=Homo sapiens GN=CALD1 PE=1 SV=3 (CALD1_HUMAN)	0.498478	0.000101
42	Q99795	Cell surface A33 antigen OS=Homo sapiens GN=GPA33 PE=1 SV=1 (GPA33_HUMAN)	0.499929	0.000108
43	P21333	Filamin-A OS=Homo sapiens GN=FLNA PE=1 SV=4 (FLNA_HUMAN)	0.502317	0.000121
44	B7Z964	Sarcolemmal membrane-associated protein OS=Homo sapiens GN=SLMAP PE=1 SV=1 (B7Z964_HUMAN)	0.503373	0.000127
45	A0A142CHG9	GO2-q chimeric G-protein OS=Homo sapiens PE=2 SV=1 (A0A142CHG9_HUMAN)	0.503463	0.000127
46	A9LSU1	Type IV collagen alpha 1 (fragment) OS=Homo sapiens PE=2 SV=1 (A9LSU1_HUMAN)	0.504429	0.000133
47	B3KM36	cDNA FLJ10153 fis, clone HEMBA1003417, highly similar to BAG family molecular chaperone regulator 2 OS=Homo sapiens PE=2 SV=1 (B3KM36_HUMAN)	0.509395	0.000165
48	Q9UMK6	Dystrophin (fragment) OS=Homo sapiens GN=DMD PE=4 SV=1 (Q9UMK6_HUMAN)	0.517995	0.000238
49	P10645	Chromogranin-A OS=Homo sapiens GN=CHGA PE=1 SV=7 (CMGA_HUMAN)	0.528393	0.000364
50	A8K2W3	cDNA FLJ78516 OS=Homo sapiens PE=2 SV=1 (A8K2W3_HUMAN)	0.530959	0.000403