Recombinant α-Klotho Protein Alleviated Acute Cardiorenal Injury in a Mouse Model of Lipopolysaccharide-Induced Septic Cardiorenal Syndrome Type 5

Figure 3

α-Klotho alleviated LPS-induced acute cardiac injury and AKI (a–f). Mice were randomly assigned to four groups (): control group, LPS group, LPS+α-klotho (0.01 mg/kg) group, and LPS+α-klotho (0.02 mg/kg) group. Recombinant α-klotho protein was injected an hour before LPS injection. Serum creatinine (a), NGAL (b), troponin (c) ,and BNP (D) levels were measured at 24 h in all groups by ELISA. Heart and kidney tissues were collected for HE staining (400x) at 24 h in four groups. The lesions in kidneys (e) and hearts (f) were marked with different arrows. means compared with the control group. .

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