Localized Amyloidosis of the Upper Aerodigestive Tract: Complex Analysis of the Cellular Infiltrate and the Amyloid Mass

Table 1

Characteristics of localized amyloidosis cases of the upper aerodigestive tract. Congo staining was performed with and without KMnO₄-trypsin pretreatment, and the slides were analysed also in polarized light. The type of cellular infiltrate and the structural and immunohistochemical characteristics of amyloid deposition were also analysed. Patient: m: male; f: female; Congo: staining with/without KMnO₄-trypsin pretreatment; IHC: κ and λ immunohistochemical staining feature of the accumulated amyloid; mRNA-ISH: messenger RNA in situ hybridization of plasma cells in the cellular infiltrate.

Patient		Anatomic site	Macroscopy	Congo	Amyloid	Microscopy	IHC	mRNA-ISH
1	61, m	Larynx (vocal+ventricular fold)	Verrucous mass	+/+	Diffuse+laminated concentric	ly+plasma cell	κ+, λ+	κ/λ: 19%/81% (1 : 4)
2	44, m	Epipharynx	Cyst	+/+	Diffuse	ly+plasma cell	κ−, λ+	κ/λ: 67%/33% (2 : 1)
3	51, f	Larynx (vocal fold+supraglottis)	Mass	+/+	Diffuse	ly+plasma cell	κ−, λ+	κ/λ: 5%/95% (1 : 19)
4	62, m	Oral cavity (palate)	Mass	+/+	Diffuse+laminated concentric	ly+plasma cell	κ+, λ−	κ/λ: 86%/14% (6 : 1)
5	31, m	Larynx (ventricular fold, right)	Mass	+/+	Diffuse+laminated concentric	ly+plasma cell	κ+, λ+	κ/λ: 16%/84% (1 : 5)