Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation
Table 3
Synopsis of the significant alterations in the immune system before (1), during (2), at the end (3), and 15 minutes after hemodialysis (4) of Tables 2 and 4.
Friedman
Wilcoxon signed-rank test
Period sample
1 to 4
1 and 2
1 and 3
1 and 4
2 and 3
2 and 4
1 and 4
Natural killer cells
0.028
0.018
0.524
0.524
0.121
0.018
0.389
Natural killer T cells
0.003
0.003
0.08
0.194
0.268
0.058
0.233
Double-negative T cells
<0.001
<0.001
0.005
<0.001
0.077
0.524
0.244
CD4+ T cells
0.001
<0.001
0.121
0.107
0.151
0.095
0.599
CD8+ T cells
0.01
0.005
0.035
0.055
0.208
0.978
0.208
CD25+ T cells
0.006
0.042
0.018
0.026
0.229
0.229
0.978
CD4+ HLA-DR+ T cells
0.039
0.002
0.454
0.561
0.169
0.173
0.303
CD8+ HLA-DR+ T cells
0.016
0.001
0.432
0.169
0.89
0.151
0.389
CD8+ naive T cells
0.165
—
—
—
—
—
—
CD8+ effector cells
0.013
0.007
0.804
0.561
0.121
0.073
0.524
CD8+ CCR5+ T cells
0.001
0.041
0.454
0.169
0.083
0.007
0.208
Regulatory T cells
0.006
0.005
0.003
0.003
0.584
0.359
0.588
HLA-DR+ Tregs
0.05
0.847
0.151
0.005
0.169
0.055
0.083
Complement CP
0.046
0.073
0.847
0.359
0.121
0.003
0.296
Complement AP
0.017
0.153
0.03
0.679
0.454
0.073
0.003
TGFβ
<0.001
<0.001
0.72
0.359
<0.001
<0.001
0.524
sCD30
0.004
0.004
0.454
0.561
0.107
<0.001
0.326
Eosinophils
0.062
—
—
—
—
—
—
Neutrophils
0.744
—
—
—
—
—
—
Blood samples: before (1), after one hour (2), at the end (3), and 15 minutes after the end of HD (4). Statistical analysis with the Friedman test and the post hoc Wilcoxon signed-rank test. values ≤ 0.003 were considered to be significant according to Bonferroni. CP: complement activation, classical pathway; AP: complement activation, alternative pathway. Not tested due to a nonsignificant Friedman test.
