Research Article
Association of JMJD2B and Hypoxia-Inducible Factor 1 Expressions with Poor Prognosis in Osteosarcoma
Table 1
Clinicopathological variables and HIF1 and JMJD2B expressions in OS patients.
| | Characteristics | | | | HIF1 | | | JMJD2B | | Low (%) | Moderate (%) | High (%) | | Low (%) | Moderate (%) | High (%) | |
| | Gender | Female | 23 | 4 (17.4) | 5 (21.7) | 14 (60.9) | 0.555 | 2 (8.7) | 8 (34.8) | 13 (56.5) | 0.471 | | Male | 30 | 5 (16.7) | 10 (33.3) | 15 (50.0) | | 5 (16.7) | 10 (33.3) | 15 (50.0) | |
| | Age | <20 years | 22 | 5 (22.7) | 5 (22.7) | 12 (54.5) | 0.752 | 9 (9.1) | 9 (40.9) | 11 (50.0) | 0.953 | | ≥20 years | 31 | 4 (12.9) | 10 (32.3) | 17 (54.8) | | 5 (16.1) | 9 (29.0) | 17 (54.8) | |
| | Tumor size | <5 cm | 24 | 5 (20.8) | 8(333) | 11(458) | 0. 253 | 4 (167) | 10 (41.7) | 10 (41.7) | 0.155 | | ≥5 cm | 29 | 4 (13.8) | 7 (24.1) | 18 (62.1) | | 3 (10.3) | 8 (27.6) | 18 (62.1) | |
| | Histologic grade | Well differentiated | 18 | 2 (11.1) | 7 (38.9) | 9 (50.0) | 0. 965 | 3 (16.7) | 7 (38.9) | 8 (44.4) | 0.757 | | Moderately differentiated | 19 | 3 (15.8) | 5 (26.3) | 11 (57.9) | | 3 (15.8) | 5 (26.3) | 11 (57.9) | | | Poorly differentiated | 16 | 4 (25.0) | 3 (18.8) | 9 (56.3) | | 1 (6.3) | 6 (27.5) | 9 (56.3) | |
| | Distant metastasis | No | 30 | 9 (30.0) | 13 (43.3) | 8 (26.7) | <0.001 | 7 (23.3) | 16 (53.3) | 7 (23.3) | <0.001 | | Yes | 23 | 0 (0.0) | 2 (8.7) | 21 (91.3) | | 0 (0.0) | 2 (8.7) | 21 (91.3) | |
| | Neoadjuvant chemotherapy | Yes | 32 | 8 (25.0) | 15 (46.9) | 9 (28.1) | <0.001 | 7 (21.9) | 16 (50.0) | 9 (28.1) | <0.001 | | No | 21 | 1 (4.8) | 0 (0.0) | 20 (95.2) | | 0 (0.0) | 2 (9.5) | 19 (90.5) | |
| | Enneking stage | I | 10 | 8 (80.0) | 2 (20.0) | 0 (0.0) | <0.001 | 6 (60.0) | 3 (30.0) | 1 (10.0) | <0.001 | | II | 18 | 1 (5.6) | 11 (61.1) | 6 (33.3) | | 1 (5.6) | 10 (55.6) | 7 (38.9) | | | III | 25 | 0 (0.0) | 2 (8.0) | 23 (54.7) | | 0 (0.0) | 5 (20.0) | 20 (80.0) | |
|
|
The Spearman-rho test was used. . |
