Molecular and Cellular Mechanisms Responsible for Beneficial Effects of Mesenchymal Stem Cell-Derived Product “Exo-d-MAPPS” in Attenuation of Chronic Airway Inflammation

Figure 4

Exo-d-MAPPS reduces the influx of inflammatory DCs and promotes the expansion of regulatory DCs in CS-injured lungs. Representative dot plots showing isotype controls (a). The total number of F4/80-CD11c+I-A+ DCs was significantly lower in the lungs of CS+Exo-d-MAPPS-treated animals, as evidenced by representative flow cytometry plots (b). A significantly decreased number of CD80-expressing (c) and IL-12-producing (d) inflammatory F4/80-CD11c+I-A+ DCs were observed in the lungs of CS+Exo-d-MAPPS-treated mice, as evidenced by representative flow cytometry plots. Exo-d-MAPPS treatment significantly increased the presence of regulatory, IL-10-producing F4/80-CD11c+I-A+ DCs in the lungs of CS-exposed animals, as evidenced by representative flow cytometry plots (e). Values are presented as ; mice/group. , , and .