Development of a Ten-lncRNA Signature Prognostic Model for Breast Cancer Survival: A Study with the TCGA Database

Table 3

Univariate and multivariate Cox regression analyses in the training, test, and entire set.

Variables		Univariable analysis			Multivariable analysis
	HR	95% CI of HR	value	HR	95% CI of HR	value
Training set ()
Age	1.021	1.004-1.038	0.014	1.016	0.999-1.034	0.055
T stage	1.574	1.183-2.094	0.002	1.166	0.812-1.674	0.405
N stage	1.588	1.275-1.979	<0.001	1.269	0.893-1.803	0.183
M stage	8.277	4.132-16.582	<0.001	3.647	1.354-9.825	0.011
Stage	2.202	1.616-2.999	<0.001	1.099	0.585-2.063	0.769
Ten-lncRNA risk score	4.203	2.462-7.176	<0.001	3.775	2.202-6.471	<0.001
Testing set ()
Age	1.013	0.994-1.032	0.170
T stage	1.312	0.947-1.819	0.103
N stage	1.337	1.062-1.682	0.013	1.113	0.758-1.635	0.585
M stage	12.332	6.231-24.408	<0.001	11.382	3.605-35.933	<0.001
Stage	2.068	1.452-2.946	<0.001	1.078	0.568-2.048	0.818
Ten-lncRNA risk score	2.885	1.636-5.088	<0.001	3.196	1.803-5.668	<0.001
Entire set ()
Age	1.018	1.005-1.030	0.006	1.017	1.005-1.030	0.007
T stage	1.445	1.166-1.791	<0.001	1.068	0.823-1.385	0.620
N stage	1.445	1.235-1.691	<0.001	1.152	0.894-1.483	0.274
M stage	10.125	6.233-16.450	<0.001	6.202	2.882-13.349	<0.001
Stage	2.1347	1.691-2.696	<0.001	1.168	0.727-1.876	0.522
Ten-lncRNA risk score	3.5227	2.388-5.196	<0.001	3.396	2.298-5.018	<0.001

HR: hazard ratio. CI: confidence interval.