MicroRNA-21-5p Reduces Hypoxia/Reoxygenation-Induced Neuronal Cell Damage through Negative Regulation of CPEB3

Figure 6

The effect of simultaneous overexpression of miR-21-5p and CPEB3 on H/R-induced cell damage (). (a) The effect of simultaneous overexpression of miR-21-5p and CPEB3 on H/R-induced cell viability. (b) The effect of cotransfection of cells with miR-21-5p mimic and CPEB3 on H/R-induced apoptosis. (c) The effect of simultaneous overexpression of miR-21-5p and CPEB3 on the expression of apoptosis-related proteins in H/R-induced cell. The experimental groups are as follows: 1: NC+H/R group; 2: miR-21-5p mimic+H/R group; 3: miR-21-5p mimic+OE-NC+H/R group; 4: miR-21-5p mimic+CPEB3+H/R group. Note: Student’s -test was used. Compared with the NC+H/R group, ^d; compared with the miR-21-5p mimic+H/R group, ^e.

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