Identification of a Seven-lncRNA-mRNA Signature for Recurrence and Prognostic Prediction in Relapsed Acute Lymphoblastic Leukemia Based on WGCNA and LASSO Analyses
Table 3
Univariate and multivariate Cox regression analyses of overall survival.
Clinical characteristics
TARGET ()
Univariate Cox
Multivariate Cox
HR (95% CI)
value
HR (95% CI)
value
Age (years, )
0.967 (0.639-0.993)
0.965 (0.903-0.989)
Sex (male/female)
61/44
0.779 (0.429-1.413)
—
—
WBC at diagnosis (IU, )
1.001 (0.999-1.003)
0.999 (0.996-1.002)
Relapse (yes/no)
10/95
1.271 (0.534-3.021)
—
—
Immunophenotype (T/B/mixture)
45/37/23
1.903 (1.260-2.875)
1.779 (0.941-2.851)
MLL rearrangement (yes/no)
8/97
3.160 (1.231-8.113)
1.664 (0.350-7.913)
Prognostic score model status (high/low)
53/52
3.409 (1.788-6.501)
3.787 (1.837-7.808)
Death (dead/alive)
44/61
—
—
—
—
Overall survival (months, )
—
—
—
—
SD: standard deviation; WBC: white blood cell; TARGET: Therapeutically Applicable Research to Generate Effective Treatments; HR: hazard ratio; CI: confidence interval; MLL: mixed lineage leukemia.