Research Article

Identification of a Seven-lncRNA-mRNA Signature for Recurrence and Prognostic Prediction in Relapsed Acute Lymphoblastic Leukemia Based on WGCNA and LASSO Analyses

Table 3

Univariate and multivariate Cox regression analyses of overall survival.

Clinical characteristicsTARGET ()Univariate CoxMultivariate Cox
HR (95% CI) valueHR (95% CI) value

Age (years, )0.967 (0.639-0.993)0.965 (0.903-0.989)
Sex (male/female)61/440.779 (0.429-1.413)
WBC at diagnosis (IU, )1.001 (0.999-1.003)0.999 (0.996-1.002)
Relapse (yes/no)10/951.271 (0.534-3.021)
Immunophenotype (T/B/mixture)45/37/231.903 (1.260-2.875)1.779 (0.941-2.851)
MLL rearrangement (yes/no)8/973.160 (1.231-8.113)1.664 (0.350-7.913)
Prognostic score model status (high/low)53/523.409 (1.788-6.501)3.787 (1.837-7.808)
Death (dead/alive)44/61
Overall survival (months, )

SD: standard deviation; WBC: white blood cell; TARGET: Therapeutically Applicable Research to Generate Effective Treatments; HR: hazard ratio; CI: confidence interval; MLL: mixed lineage leukemia.