“Derived Multiple Allogeneic Protein Paracrine Signaling (d-MAPPS)” Enhances T Cell-Driven Immune Response to Murine Mammary Carcinoma

<div>d-MAPPS increased number of tumoricidal CD8+ CTLs and decreased presence of immunosuppressive CD8+ T cells in the tumors of 4T1-treated mice. Total number of (a) tumorotoxic CD178+CD8+ CTLs, (b) granzyme B-expressing CD8+ CTLs, (c) IFN-<i>γ</i>-producing CD8+ Th1, and (d) IL-17-producing CD8+ Th17 cells and percentage of (e) immunosuppressive IL-10-producing CD8+ and (f) FoxP3-expressing CD8+ T regulatory cells in the tumors of 4T1+saline-treated (black bars) and 4T1+d-MAPPS-treated mice (white bars), as determined by the flow cytometry analysis and intracellular staining of tumor-infiltrated mononuclear cells. 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Analytical Cellular Pathology

fig6

Figure 6

Figure 6: “Derived Multiple Allogeneic Protein Paracrine Signaling (d-MAPPS)” Enhances T Cell-Driven Immune Response to Murine Mammary Carcinoma 