Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer

<div>Anlotinib combined with 5-FU induces cell apoptosis in the H446 cells. The cells were treated with anlotinib and 5-FU or combination of both for 24 hours. Apoptosis determined by annexin V-FITC/PI staining by flow cytometry. (a) The H446 cells were treated with anlotinib (5 <i>μ</i>M) and 5-FU (10 <i>μ</i>M) or combination of both. (b) The apoptosis rate (%) included Q3 and Q4. All experiments were repeated three times. 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Analytical Cellular Pathology

fig2

Figure 2

Figure 2: Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer 

Figure 2 | Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer 