Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60^∗G Allele

Table 2

The results of the binary logistic regression analyses considering the CT60*GG genotype, the CT60*G allele, and the +49*G-CT60*G haplotype in RA patients stratified by RF- and anti-CCP-seropositivity versus controls.

	RA Patients
		RF		anti-CCP		RF + anti-CCP
	Total	Positive	Negative	Positive	Negative	Positive-positive	Negative-negative
CT60*GG
OR (95%CI)	1.56 (1.09–2.23)	1.76 (1.21–2.56)	1.01 (0.59–1.73)	1.92 (1.32–2.79)	0.82 (0.48–1.39)	1.90 (1.29–2.78)	0.76 (0.41–1.42)
𝑃	.016	.003	.966	.001	.455	.001	.386
CT60*G
OR (95%CI)	1.42 (1.13–1.78)	1.52 (1.20–1.93)	1.15 (0.83–1.60)	1.58 (1.24–2.02)	1.06 (0.78–1.46)	1.58 (1.23–2.03)	1.04 (0.72–1.49)
𝑃	.003	.001	.410	<.001	.145	<.001	.845
+49*G - CT60*G
OR (95%CI)	1.73 (1.27–2.37)	1.88 (1.36–2.61)	1.30 (0.83–2.04)	2.00 (1.44–2.76)	1.12 (0.71–1.75)	1.96 (1.41–2.73)	1.02 (0.61–1.73)
𝑃	.001	<0 .001	.256	<0 .001	0.626	<.001	.931