Pathogenic and Epiphenomenal Anti-DNA Antibodies in SLE

Table 1

Anti-DNA autoantibodies in SLE both belong to category of ANA 95%–98% Titer: 1 : 80 or lower is considered negative.

dsDNA	ssDNA
SPECIFICITY	SPECIFICITY
(i) Highly specific for SLE [18]	(i) NonSpecific [18]
(ii) Considered traditional markers of SLE	(ii) Rarely indicated
TEST SENSITIVITY	TEST-SENSITIVITY
(i) 60%	(i) 30%–70%
PRODUCERS (?)	PRODUCERS (?)
(i) 55%–75% of premature B-cells are prone to autoreactivity [18]	(i) CD5+/CD5- [39]
(ii) CD5+/CD5-[39]	(ii) RP105- [19]
(iii) RP105-[19]	(iii) RP105+ [19]
(iv) 𝑋=19.5%
(v) (Range: 8.8%–31%)