Inflammation and Epstein-Barr Virus Infection Are Common Features of Myasthenia Gravis Thymus: Possible Roles in Pathogenesis

Table 1

Clinical features of MG patients included in the study.

Patient Group 1	Hyperplasia (n = 3)	Thymitis (n = 3)	Involuted (n = 4)
Sex (F/M)	3/0	2/1	2/2
Age at disease onset (years) mean ± SD	23.3±9.3	30.9±3.7	29.1±16.3
Age at surgery (years) mean ± SD	26.3±11.0	32.0±3.6	31.5±15.2
Ab AChR-positive	2	3	4
Seronegative	1	0	0
Immunosuppressive therapy	2	2	4
Patient Group 2	Hyperplasia (𝑛=6)	Thymitis (𝑛=6)	Involuted (𝑛=5)
Sex (F/M)	5/1	5/1	4/1
Age at disease onset (years)^a mean ± SD	23.6±7.2	23.4±12.6	30.0±10.2
Age at surgery (years) mean ± SD	25.5±6.0	25.2±11.9	33.0±11.2
Ab AChR-positive	6	4^b	4
Seronegative	0	1	1
Immunosuppressive therapy	5^c	4	5
Patient Group 3	Hyperplasia (𝑛=9)	Thymitis (𝑛=5)	Involuted (𝑛=5)
Sex (F/M)	8/1	4/1	3/2
Age at disease onset (years)^d mean ± SD	26.4±9.2	31.0±3.8	30.7±14.4
Age at surgery (years) mean ± SD	30.0±10.9	33.4±4.0	32.20±11.8
Ab AChR-positive	6	4	5
Seronegative	3	1	0
Immunosuppressive therapy	3	4	5

^aAge at disease onset was not available for two patients, one with hyperplasia and one with thymitis. ^bInformation on autoantibody presence in serum was not available in one patient. ^cData on the therapy before thymectomy were missing in one patient. ^dAge at disease onset was not available for two patients, one with hyperplasia and one with involuted thymus.