Table 3: Detection of EBV DNA and RNA transcripts in MG thymus by real-time PCR.

PatientThymic pathologyAnti-AChR antibodiesaEBV DNAbLatent markersbLytic markerb
EBER1EBNA1LMP1BZLF1

MG1HyperplasiaPositive++++
MG2HyperplasiaPositive+++++
MG3HyperplasiaPositive++
MG4HyperplasiaPositive+++
MG5HyperplasiaPositive+++++
MG6HyperplasiaPositive+++++
MG7HyperplasiaSN+++
MG8HyperplasiaSN++
MG9HyperplasiaSN++++

MG10ThymitisPositive++
MG11ThymitisPositive+++
MG12ThymitisPositive+
MG13ThymitisPositive+++
MG14ThymitisSN+++

MG15InvolutedPositive+++
MG16InvolutedPositive+++++
MG17InvolutedPositive+++++
MG18InvolutedPositive+++++
MG19InvolutedPositive+++

Ctr1cNormalSN
Ctr2cNormalSN

aSN: seronegative (AChR- and MuSK-negative) patients. bEBV genome and transcripts were analysed by real-time PCR techniques as described in Section 2. Results are expressed as follows: + detected (Ct value <38); − not detected (Ct value >38). cCtr: nonpathological control thymus.