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Autoimmune Diseases
Volume 2011, Article ID 250561, 6 pages
http://dx.doi.org/10.4061/2011/250561
Review Article

Anaesthetic Considerations in Paediatric Myasthenia Gravis

Birmingham Children's Hospital, Birmingham B4 6NH, UK

Received 31 May 2011; Accepted 2 August 2011

Academic Editor: Shigeaki Suzuki

Copyright © 2011 Oliver William Masters and Oliver N. Bagshaw. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myasthenia gravis is of particular interest to anaesthetists because of the muscle groups affected, the pharmacology of the neuromuscular junction, and interaction of both the disease and treatment with many anaesthetic drugs. Anaesthetists may encounter children with myasthenia either to facilitate treatment options or to institute mechanical ventilation in the face of a crisis. This paper reviews the literature pertaining to the pathophysiology and applied pharmacology of the disease and explores the relationship between these and the anaesthetic management. In addition to illustrating the tried-and-tested techniques, some newer management options are explored.