Research Article
The Caspase Pathway as a Possible Therapeutic Target in Experimental Pemphigus
Table 1
Pemphigus IgG triggers acantholysis in Balb/c mice.
| | Group () | (A) Control | (B) PV-IgG | (C) Ac-DEVD-CMK+PV-IgG | P value |
| | Macroscopic blisters | 0/9 | 7/9 | 0/9 | A versus B < .0037 | | B versus C < .0037 | | Histology | Normal | Blisters, acantholysis 7/9 | No blisters | A versus B < .0037 | | B versus C < .0037 | | Direct immunofluorescence | Negative | IgG on intercellular spaces 9/9 | IgG on intercellular spaces 9/9 | A versus B < .0002 | | B versus C > .37 | | TUNEL | Negative | Positive 9/9 | Negative | A versus B < .0002 | | B versus C < .0002 | | Annexin | Negative | Positive 9/9 | Negative | A versus B < .0002 | | B versus C < .0002 | | Caspase 3 | 0/9 | 9/9 | 0/9 | A versus B < .0002 | | B versus C < .0002 | | Fas | 9/9 faint | 9/9 strong | 9/9 faint | A versus B > .3 | | B versus C >.32 | | FasL | 1/9 | 9/9 | 2/9 faint | A versus B < .0009 | | B versus C < .0017 |
|
|
PV: pemphigus vulgaris, (statistically significant < 0.05), Chi-squared with Yates’ correction.
|
